Физиологический континуум пластичности и патологии нервной системы

Авторы

  • Наталия Валерьевна Гуляева Институт высшей нервной деятельности и нейрофизиологии РАН; Научно-практический психоневрологический центр имени З. П. Соловьева Департамента здравоохранения города Москвы https://orcid.org/0000-0002-5380-7954

DOI:

https://doi.org/10.33910/2687-1270-2020-1-4-294-302

Ключевые слова:

интегративная физиология, мозг, нейропластичность, гиппокамп, молекулярные механизмы, патология

Аннотация

В статье рассматривается концепция о континууме нейропластичности и нейропатологии с точки зрения интегративной физиологии. Общность и плейотропность механизмов на молекулярном, синаптическом, клеточном и сетевом уровне ассоциирована с высокой адаптивной пластичностью отделов мозга (например, гиппокампа), ответственных за его интегративную функцию, в т. ч. обучение и память. Однако ценой высокой пластичности является селективная чувствительность этих структур к развитию патологических процессов. При этом, в зависимости от конкретной патологии, нейропластичность может снижаться (в результате гибели нейронов и снижения нейрогенеза, например, при нейродегенеративных заболеваниях) или повышаться (аберрантная пластичность при эпилептогенезе). Наряду с фундаментальным значением представления о континууме нейропластичности для понимания процессов, происходящих в мозге в норме и при патологии, концепция о континууме принципиально важна и с практической точки зрения, поскольку позволяет оценивать целесообразность вмешательства в конкретный процесс, вовлеченный как в патогенез заболевания мозга, так и в реализацию нормальной адаптивной пластичности.

Библиографические ссылки

ЛИТЕРАТУРА

Балабан, П. М., Гуляева, Н. В. (2006) Общность молекулярных механизмов нейропластичности и нейропатологии: интегративный подход. Российский физиологический журнал им. И. М. Сеченова, т. 92, № 2, с. 145–152.

Гуляева, Н. В. (2015) Нейропластичность и эпилепсия: современные концепции и механизмы коморбидности эпилепсии и депрессии. Журнал неврологии и психиатрии им. С. С. Корсакова, т. 115, № 12, с. 148–153. DOI: 10.17116/jnevro2015115112148-153

Гуляева, Н. В. (2016) Пластичность мозга и коннектопатии: механизмы коморбидности неврологических заболеваний и депрессии. Журнал неврологии и психиатрии им. С. С. Корсакова, т. 116, № 11, с. 157–162. DOI: 10.17116/jnevro2016116111157-162

Гуляева, Н. В. (2017) Стадийность изменений нейропластичности при эпилептогенезе на примере височной эпилепсии. Журнал неврологии и психиатрии им. С. С. Корсакова, т. 117, № 9, с. 10–16. DOI: 10.17116/jnevro20171179210-16

Меерсон, Ф. З. (1973) Общий механизм адаптации и профилактики. М.: Наука, 360 с.

Меерсон, Ф. З. (1981) Адаптация, стресс и профилактика. М.: Наука, 278 с.

Меерсон, Ф. З. (1986) О “цене” адаптации. Патологическая физиология и экспериментальная терапия, № 3, с. 9–19.

Cohen, E. J., Quarta, E., Bravi, R. et al. (2017) Neural plasticity and network remodeling: From concepts to pathology. Neuroscience, vol. 344, pp. 326–345. DOI: 10.1016/j.neuroscience.2016.12.048

Dingledine, R., Varvel, N. H., Dudek, F. E. (2014) When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? In: H. Scharfman, P. Buckmaster (eds.). Issues in clinical epileptology: A view from the bench. Dordrecht: Springer, pp. 109–122. (Advances in experimental medicine and biology. Vol. 813). DOI: 10.1007/978-94-017-8914-1_9

Gulyaeva, N. V. (2003) Non-apoptotic functions of caspase-3 in nervous tissue. Biochemistry (Moscow), vol. 68, no. 11, pp. 1171–1180. DOI: 10.1023/b:biry.0000009130.62944.35

Gulyaeva, N. V. (2015) Ventral hippocampus, stress and psychopathology: Translational implications. Neurochemical Journal, vol. 9, no. 2, pp. 85–94. DOI: 10.1134/S1819712415020075

Gulyaeva, N. V. (2017) Molecular mechanisms of neuroplasticity: An expanding universe. Biochemistry (Moscow), vol. 82, no. 3, pp. 237–242. DOI: 10.1134/S0006297917030014

Gulyaeva, N. V. (2019a) Biochemical mechanisms and translational relevance of hippocampal vulnerability to distant focal brain injury: The price of stress response. Biochemistry (Moscow), vol. 84, no. 11, pp. 1306–1328. DOI: 10.1134/S0006297919110087

Gulyaeva, N. V. (2019b) Functional neurochemistry of the ventral and dorsal hippocampus: Stress, depression, dementia and remote hippocampal damage. Neurochemical Research, vol. 44, no. 6, pp. 1306–1322. DOI: 10.1007/s11064-018-2662-0

Jaworski, T., Banach-Kasper, E., Gralec, K. (2019) GSK-3β at the intersection of neuronal plasticity and neurodegeneration. Neural Plasticity, vol. 2019, article 4209475. DOI: 10.1155/2019/4209475

Kudryashov, I. E., Yakovlev, A. A., Kudryashova, I. V., Gulyaeva, N. V. (2004) Inhibition of caspase-3 blocks long-term potentiation in hippocampal slices. Neuroscience and Behavioral Physiology, vol. 34, no. 9, pp. 877–880. DOI: 10.1023/b:neab.0000042571.86110.28

Kudryashova, I. V., Stepanichev, M. Yu., Gulyaeva, N. V. (2009) Natural activation of caspase-3 is required for the development of operant behavior in postnatal ontogenesis. Neuroscience and Behavioral Physiology, vol. 39, no. 1, pp. 65–72. DOI: 10.1007/s11055-008-9097-z

Mattson, M. P. (1998) Free radicals, calcium, and the synaptic plasticity-cell death continuum: Emerging roles of the transcription factor NFkB. International Review of Neurobiology, vol. 42, pp. 103–168. DOI: 10.1016/s0074-7742(08)60609-1

Mattson, M. P., Duan, W. (1999) “Apoptotic” biochemical cascades in synaptic compartments: Roles in adaptive plasticity and neurodegenerative disorders. Journal of Neuroscience Research, vol. 58, no. 1, pp. 152–166. DOI: 10.1002/(SICI)1097-4547(19991001)58:1<152::AID-JNR15>3.0.CO;2-V

McEachern, J. C., Shaw, C. A. (1996) An alternative to the LTP orthodoxy: A plasticity-pathology continuum model. Brain Research Reviews, vol. 22, no. 1, pp. 51–92. DOI: 10.1016/0165-0173(96)00006-9

McEachern, J. C., Shaw, C. A. (1999) The plasticity-pathology continuum: Defining a role for the LTP phenomenon. Journal of Neuroscience Research, vol. 58, no. 1, pp. 42–61.

McEwen, B. S. (1998) Stress, adaptation, and disease: Allostasis and allostatic load. Annals of New York Academy of Sciences, vol. 840, no. 1, pp. 33–44. DOI: 10.1111/j.1749-6632.1998.tb09546.x

McEwen, B. S., Stellar, E. (1993) Stress and the individual. Mechanisms leading to disease. Archives of Internal Medicine, vol. 153, no. 18, pp. 2093–2101.

Meerson, F. Z., Pshennikova, M. G., Malyshev, I. Yu. (1996) Adaptive defense of the organism. Architecture of the structural trace and cross protective effects of adaptation. Annals of New York Academy of Sciences, vol. 793, no. 1, pp. 371–385. DOI: 10.1111/j.1749-6632.1996.tb33529.x

Piskunov, A., Stepanichev, M., Tishkina, A. et al. (2016) Chronic combined stress induces selective and long-lasting inflammatory response evoked by changes in corticosterone accumulation and signaling in rat hippocampus. Metabolic Brain Disease, vol. 31, no. 2, pp. 445–454. DOI: 10.1007/s11011-015-9785-7

Schwartzkroin, P. A. (2001) Mechanisms of brain plasticity: From normal brain function to pathology. International Review of Neurobiology, vol. 45, no. 1, pp. 1–15. DOI: 10.1016/s0074-7742(01)45004-5

Stepanichev, M. Yu., Kudryashova, I. V., Yakovlev, A. A. et al. (2005) Central administration of a caspase inhibitor impairs shuttle-box performance in rats. Neuroscience, vol. 136, no. 2, pp. 579–591. DOI: 10.1016/j.neuroscience.2005.08.010

Yakovlev, A. A., Gulyaeva, N. V. (2011) Pleiotropic functions of brain proteinases: Methodological considerations and search for caspase substrates. Biochemistry (Moscow), vol. 76, no. 10, article 1079. DOI: 10.1134/S0006297911100014

REFERENCES

Balaban, P. M, Gulyaeva, N. V. (2006) Obshchnost’ molekulyarnykh mekhanismov neiroplastichnosti i neiropatologii: integrativnyi podkhod [Commonality of molecular mechanisms of neuroplasticity and neuropathology: Integrative approach]. Rossiyskij Fiziologicheskij Zhurnal imeni I. M. Sechenova — Russian Journal of Physiology, vol. 92, no. 2, pp. 145–152. (In Russian).

Cohen, E. J., Quarta, E., Bravi, R. et al. (2017) Neural plasticity and network remodeling: From concepts to pathology. Neuroscience, vol. 344, pp. 326–345. DOI: 10.1016/j.neuroscience.2016.12.048 (In English)

Dingledine, R., Varvel, N. H., Dudek, F. E. (2014) When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? In: H. Scharfman, P. Buckmaster (eds.). Issues in clinical epileptology: A view from the bench. Dordrecht: Springer, pp. 109–122. (Advances in experimental medicine and biology. Vol. 813). DOI: 10.1007/978-94-017-8914-1_9 (In English)

Gulyaeva, N. V. (2003) Non-apoptotic functions of caspase-3 in nervous tissue. Biochemistry (Moscow), vol. 68, no. 11, pp. 1171–1180. DOI: 10.1023/b:biry.0000009130.62944.35 (In English)

Gulyaeva, N. V. (2015) Ventral hippocampus, stress and psychopathology: Translational implications. Neurochemical Journal, vol. 9, no. 2, pp. 85–94. DOI: 10.1134/S1819712415020075 (In English)

Gulyaeva, N. V. (2015 Neiroplastichnost’ i epilepsiya: sovremennye kontseptsii i mekhanismy komorbidnosti epilepsii i depressii [Neuronal plasticity and epilepsy: Modern concepts and mechanisms of epilepsy and depression comorbidity]. Zhurnal nevrologii i psikhiatrii imeni S. S. Korsakova — S. S. Korsakov Journal of Neurology and Psychiatry, vol. 115, no. 12, pp. 148–153. DOI: 10.17116/jnevro2015115112148-153 (In Russian)

Gulyaeva, N. V. (2016) Plastichnost’ mozga i konnektopatii: mekhanizmy komorbidnosti nevrologicheskikh zabolevanij i depressii [Cerebral plasticity and connectopathies: Mechanisms of comorbidity of neurological diseases and depression]. Zhurnal nevrologii i psikhiatrii imeni S. S. Korsakova — S. S. Korsakov Journal of Neurology and Psychiatry, vol. 116, no. 11, pp. 157–162. DOI: 10.17116/jnevro2016116111157-162 (In Russian)

Gulyaeva, N. V. (2017) Molecular mechanisms of neuroplasticity: An expanding universe. Biochemistry (Moscow), vol. 82, no. 3, pp. 237–242. DOI: 10.1134/S0006297917030014 (In English)

Gulyaeva, N. V. (2017) Stadijnost’ izmenenij neiroplastichnosti pri epileptogeneze na primere visochnoj epilepsii [Staging of neuroplasticity alterations during epileptogenesis (temporal lobe epileply as an example)]. Zhurnal nevrologii i psikhiatrii imeni S. S. Korsakova — S. S. Korsakov Journal of Neurology and Psychiatry, vol. 117, no. 9, pp. 10–16. DOI: 10.17116/jnevro20171179210-16 (In Russian)

Gulyaeva, N. V. (2019a) Biochemical mechanisms and translational relevance of hippocampal vulnerability to distant focal brain injury: The price of stress response. Biochemistry (Moscow), vol. 84, no. 11, pp. 1306–1328. DOI: 10.1134/S0006297919110087 (In English)

Gulyaeva, N. V. (2019b) Functional neurochemistry of the ventral and dorsal hippocampus: Stress, depression, dementia and remote hippocampal damage. Neurochemical Research, vol. 44, no. 6, pp. 1306–1322. DOI: 10.1007/s11064-018-2662-0 (In English)

Jaworski, T., Banach-Kasper, E., Gralec, K. (2019) GSK-3β at the intersection of neuronal plasticity and neurodegeneration. Neural Plasticity, vol. 2019, article 4209475. DOI: 10.1155/2019/4209475 (In English)

Kudryashov, I. E., Yakovlev, A. A., Kudryashova, I. V., Gulyaeva, N. V. (2004) Inhibition of caspase-3 blocks long-term potentiation in hippocampal slices. Neuroscience and Behavioral Physiology, vol. 34, no. 9, pp. 877–880. DOI: 10.1023/b:neab.0000042571.86110.28 (In English)

Kudryashova, I. V., Stepanichev, M. Yu., Gulyaeva, N. V. (2009) Natural activation of caspase-3 is required for the development of operant behavior in postnatal ontogenesis. Neuroscience and Behavioral Physiology, vol. 39, no. 1, pp. 65–72. DOI: 10.1007/s11055-008-9097-z (In English)

Mattson, M. P. (1998) Free radicals, calcium, and the synaptic plasticity-cell death continuum: Emerging roles of the transcription factor NFkB. International Review of Neurobiology, vol. 42, pp. 103–168. DOI: 10.1016/s0074-7742(08)60609-1 (In English)

Mattson, M. P., Duan, W. (1999) “Apoptotic” biochemical cascades in synaptic compartments: Roles in adaptive plasticity and neurodegenerative disorders. Journal of Neuroscience Research, vol. 58, no. 1, pp. 152–166. DOI: 10.1002/(SICI)1097-4547(19991001)58:1<152::AID-JNR15>3.0.CO;2-V (In English)

McEachern, J. C., Shaw, C. A. (1996) An alternative to the LTP orthodoxy: A plasticity-pathology continuum model. Brain Research Reviews, vol. 22, no. 1, pp. 51–92. DOI: 10.1016/0165-0173(96)00006-9 (In English)

McEachern, J. C., Shaw, C. A. (1999) The plasticity-pathology continuum: Defining a role for the LTP phenomenon. Journal of Neuroscience Research, vol. 58, no. 1, pp. 42–61. (In English)

McEwen, B. S. (1998) Stress, adaptation, and disease: Allostasis and allostatic load. Annals of New York Academy of Sciences, vol. 840, no. 1, pp. 33–44. DOI: 10.1111/j.1749-6632.1998.tb09546.x (In English)

McEwen, B. S., Stellar, E. (1993) Stress and the individual. Mechanisms leading to disease. Archives of Internal Medicine, vol. 153, no. 18, pp. 2093–2101. (In English)

Meerson, F. Z. (1973) Obshchii mekhanism adaptatsii i profilaktiki [The general mechanism of adaptation and prophylaxis]. Moscow: Nauka Publ., 360 p. (In Russian)

Meerson, F. Z. (1981) Adaptatsiya, stress i profilaktika [Adaptation, stress, and prophylaxis]. Moscow: Nauka Publ., 278 p. (In Russian)

Meerson, F. Z. (1986) O “tsene” adaptatsii [The “cost” of adaptation]. Patologicheskaya fiziologiya i eksperimental’naya terapiya — Pathological Physiology and Experimental Therapy, no. 3, pp. 9–19. (In Russian)

Meerson, F. Z., Pshennikova, M. G., Malyshev, I. Yu. (1996) Adaptive defense of the organism. Architecture of the structural trace and cross protective effects of adaptation. Annals of New York Academy of Sciences, vol. 793, no. 1, pp. 371–385. DOI: 10.1111/j.1749-6632.1996.tb33529.x (In English)

Piskunov, A., Stepanichev, M., Tishkina, A. et al. (2016) Chronic combined stress induces selective and long-lasting inflammatory response evoked by changes in corticosterone accumulation and signaling in rat hippocampus. Metabolic Brain Disease, vol. 31, no. 2, pp. 445–454. DOI: 10.1007/s11011-015-9785-7 (In English)

Schwartzkroin, P. A. (2001) Mechanisms of brain plasticity: From normal brain function to pathology. International Review of Neurobiology, vol. 45, no. 1, pp. 1–15. DOI: 10.1016/s0074-7742(01)45004-5 (In English)

Stepanichev, M. Yu., Kudryashova, I. V., Yakovlev, A. A. et al. (2005) Central administration of a caspase inhibitor impairs shuttle-box performance in rats. Neuroscience, vol. 136, no. 2, pp. 579–591. DOI: 10.1016/j.neuroscience.2005.08.010 (In English)

Yakovlev, A. A., Gulyaeva, N. V. (2011) Pleiotropic functions of brain proteinases: Methodological considerations and search for caspase substrates. Biochemistry (Moscow), vol. 76, no. 10, article 1079. DOI: 10.1134/S0006297911100014 (In English)

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2020-12-28

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