Психосоциальный стресс перенаселенности (скученности): негативные последствия для организма человека и грызунов

Авторы

  • Елена Владимировна Лосева Институт высшей нервной деятельности и нейрофизиологии РАН https://orcid.org/0000-0003-0941-670X

DOI:

https://doi.org/10.33910/2687-1270-2021-2-1-33-40

Ключевые слова:

психосоциальный стресс, перенаселенность, общество, скученность, грызуны, нервная система, поведение, моноамины мозга, иммунитет

Аннотация

Обзор посвящен анализу литературных и собственных данных о негативных последствиях психосоциального стресса перенаселенности в обществе для организма человека, а также о влиянии скученности (экспериментальной модели перенаселенности) в условиях вивария на организм грызунов (крыс и мышей). Наибольшее внимание при анализе экспериментальных работ, в том числе и собственных, на грызунах уделено влиянию скученности на общее состояние организма, развитие стресс-реакции, содержание моноаминов и их метаболитов в мозге, состояние иммунной системы — цитокиновый профиль и интерфероновый статус. Сделано заключение, что долговременная скученность у грызунов (главным образом крыс) в условиях вивария является мощным стрессором, при котором ухудшается общее состояние организма, развивается тревожно-депрессивное поведение, нарушается деятельность гипоталамо-гипофизарно-адреналовой системы, происходит дисбаланс моноаминов и их метаболитов в ряде структур мозга, снижается иммунитет. В собственных экспериментах применялась интенсивная стрессовая модель скученности в ограниченном пространстве, при которой крысы-самцы после месяца жизни в стандартных условиях вивария (4–6 особей в клетке) помещались в скученные условия (15–17 особей в клетке) на длительное время (две недели). Предполагается, что такая модель может быть использована для доклинической оценки анксиолитических, антидепрессивных, иммуномодулирующих и других свойств различных биологически активных веществ и препаратов, которые могут быть полезны для коррекции негативных последствий долговременных психосоциальных стрессов.

Библиографические ссылки

Aioi, A., Okuda, M., Matsui, M. et al. (2001) Effect of high population density environment on skin barrier function in mice. Journal of Dermatological Science, vol. 25, no. 3, pp. 189–197. https://www.doi.org/10.1016/s0923-1811(00)00133-x (In English)

Anacker, A. M., Ryabinin, A. E. (2010) Biological contribution to social influences on alcohol drinking: Evidence from animal models. International Journal of Environmental Research and Public Health, vol. 7, no. 2, pp. 473–493. https://www.doi.org/10.3390/ijerph7020473 (In English)

Andrejević, S., Bukilica, M., Dimitrijević, M. et al. (1997) Stress-induced rise in serum anti-brain autoantibody levels in the rat. International Journal of Neuroscience, vol. 89, no. 3–4, pp. 153–164. https://www.doi.org/10.3109/00207459708988471 (In English)

Armario, A., Castellanos, J. M., Balasch, J. (1984) Effect of crowding on emotional reactivity in male rats. Neuroendocrinology, vol. 39, no. 4, pp. 330–333. https://www.doi.org/10.1159/000124000 (In English)

Armitage, D. (2004) Rattus norvegicus. Animal Diversity Web. [Online]. Available at: https://animaldiversity.org/accounts/Rattus_norvegicus/ (accessed 31.01.2021). (In English)

Boranic, M., Pericic, D., Radacic, M. et al. (1982) Immunological and neuroendocrine responses of rats to prolonged or repeated stress. Biomedicine & Pharmacotherapy, vol. 36, no. 1, pp. 23–28. PMID: 6127122. (In English)

Botelho, S., Estanislau, C., Morato, S. (2007) Effects of under- and overcrowding on exploratory behavior in the elevated plus-maze. Behavioural Processes, vol. 74, no. 3, pp. 357–362. https://www.doi.org/10.1016/j.beproc.2006.12.006 (In English)

Brown, K. J., Grunberg, N. E. (1995) Effects of housing on male and female rats: Crowding stresses male but calm females. Physiology and Behavior, vol. 58, no. 6, pp. 1085–1089. https://www.doi.org/10.1016/0031-9384(95)02043-8 (In English)

Bugajski, J., Borycz, J., Glod, R., Bugajski, A. J. (1995) Crowding stress impairs the pituitary-adrenocortical responsiveness to the vasopressin but not corticotropin-releasing hormone stimulation. Brain Research, vol. 681, no. 1–2, pp. 223–228. https://www.doi.org/10.1016/0006-8993(95)00297-4 (In English)

Calhoun, J. B. (1962) Population density and social pathology. Scientific American, vol. 206, no. 2, pp. 139–150. (In English)

Chawińska, E., Tukiendorf, A., Miszczyk, L. (2014) Interrelation between population density and cancer incidence in the province of Opole, Poland. Contemporary Oncology (Poznań, Poland), vol. 18, no. 5, pp. 367–370. https://www.doi.org/10.5114/wo.2014.44122 (In English)

Christian, J. J. (1963) The pathology of overpopulation. Military Мedicine, vol. 128, no. 7, pp. 571–603. https://doi.org/10.1093/milmed/128.7.571 (In English)

Costa e Silva, J. A., Steffen, R. E. (2019) Urban environment and psychiatric disorders: A review of the neuroscience and biology. Metabolism, vol. 100, article 153940. https://www.doi.org/10.1016/j.metabol.2019.07.004 (In English) Csermely, P., Pénzes, I., Tóth, S. (1995) Chronic overcrowding decreases cytoplasmic free calcium levels in T lymphocytes of aged CBA/CA mice. Experientia, vol. 51, no. 9–10, pp. 976–979. https://www.doi.org/10.1007/BF01921751 (In English)

Daniels, W. M. U., Pietersen, C. Y., Carstens, M. E. et al. (2000) Overcrowding induces anxiety and causes loss of serotonin 5HT-1a receptors in rats. Metabolic Brain Disease, vol. 15, no. 4, pp. 287–295. https://www.doi.org/10.1023/a:1011123208674 (In English)

Djordjević, J., Cvijić, G., Davidović, V. (2003) Different activation of ACTH and corticosterone release in response to various stressors in rats. Physiological Research, vol. 52, no. 1, pp. 67–72. PMID: 12625809. (In English)

Fabiana, A., Donia, D., Gabrieli, R. et al. (2007) Influence of enteric viruses on gastroenteritis in Albania: Epidemiological and molecular analysis. Journal of Medical Virology, vol. 79, no. 12, pp. 1844–1849. https://www.doi.org/10.1002/jmv.21001 (In English)

Gadek-Michalska, A., Bugajski, A. J., Bugajski, J. (2008) Prostaglandins and interleukin-1beta in the hypothalamic-pituitary-adrenal response to systemic phenylephrine under basal and stress conditions. Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society, vol. 59, no. 3, pp. 563–575. PMID: 18953098. (In English)

Goeckner, D. J., Greenough, W. T., Mead, W. R. (1973) Deficits in learning tasks following chronic overcrowding in rats. Journal of Personality and Social Psychology, vol. 28, no. 2, pp. 256–261. https://www.doi.org/10.1037/h0035783 (In English)

Hoge, C. W., Reichler, M. R., Dominguez, E. A. et al. (1994) An epidemic of pneumococcal disease in an overcrowded, inadequately ventilated jail. New England Journal of Medicine, vol. 331, no. 10, pp. 643–648. https://www.doi. org/10.1056/NEJM199409083311004 (In English)

Knyazeva, S. I., Loginova, N. A., Loseva, E. V. (2012) Anxiety level and body weight changes in rats living in overpopulated cages. Bulletin of Experimental Biology and Medicine, vol. 154, no. 1, pp. 3–6. https://www.doi.org/10.1007/s10517-012-1860-z (In English)

Lederbogen, F., Kirsch, P., Haddad, L. et al. (2011) City living and urban upbringing affect neural social stress processing in humans. Nature, vol. 474, no. 7352, pp. 498–501. https://www.doi.org/10.1038/nature10190 (In English)

Lin, E.-J. D., Sun, M., Choi, E. Y. et al. (2015) Social overcrowding as a chronic stress model that increases adiposity in mice. Psychoneuroendocrinology, vol. 51, pp. 318–330. https://www.doi.org/10.1016/j.psyneuen.2014.10.007 (In English)

Loseva, E. V., Loginova, N. A., Mezentseva, M. V. et al. (2013) Immunological parameters of the blood and monoamine content in the brain of rats during long-term overcrowding. Bulletin of Experimental Biology and Medicine, vol. 155, no. 4, pp. 470–473. https://www.doi.org/10.1007/s10517-013-2181-6 (In English)

Loseva, E. V., Sarkisova, K. Yu., Loginova, N. A., Kudrin, V. S. (2015) Depressive behavior and monoamine contents in brain structures of rats during chronic overcrowding. Bulletin of Experimental Biology and Medicine, vol. 159, no. 3, pp. 327–330. https://www.doi.org/10.1007/s10517-015-2953-2 (In English)

Love, J., Zelikowsky, M. (2020) Stress varies along the social density continuum. Frontiers in Systems Neuroscience, vol. 14, article 582985. https://www.doi.org/10.3389/fnsys.2020.582985 (In English)

Martín, P. I., Sánchez, P. A., Rewald, E. (2009) Microparticles and the hygiene hypothesis. Annals of the New York Academy of Sciences, vol. 1173, no. 1, pp. 409–421. https://www.doi.org/10.1111/j.1749-6632.2009.04920.x (In English)

Moiseeva, Ju. V., Khonicheva, N. M., Ajrapetyants, M. G. et al. (2009) Povyshenie urovnya trevozhnosti u krys, vyzvannoe sotsial’nym stressom perenaseleniya, ne soprovozhdaetsya izmeneniyami nitrergicheskoj sistemy v mozge [Increase of anxiety level in rats caused by social stress of overpopulation not followed by changes of nitrergic system in the brain]. Nejrokhimiya — Neurochemical Journal, vol. 26, no. 1, pp. 64–71. (In Russian)

Morrison, B. J., Thatcher, K. (1969) Overpopulation effects on social reduction of emotionality in the albino rat. Journal of Comparative and Physiological Psychology, vol. 69, no. 4, pp. 658–662. https://www.doi.org/10.1037/h0028202 (In English)

Myers, D. G. (2007) Sotsial’naya psikhologiya: intensivnyj kurs [Exploring social psychology]. Saint Petersburg: Prajm-Yevroznak Publ., 512 p. (In Russian)

Nagaraja, H. S., Jeganathan, P. S. (1999) Influence of different types of stress on selected cardiovascular parameters in rats. Indian Journal of Physiology and Pharmacology, vol. 43, no. 3, pp. 296–304. PMID: 10776477. (In English)

Nagaraja, H. S., Jeganathan, P. S. (2003) Effect of acute and chronic conditions of over-crowding on free choice ethanol intake in rats. Indian Journal of Physiology and Pharmacology, vol. 47, no. 3, pp. 325–331. PMID: 14723319. (In English)

Naitoh, H., Nomura, S., Kunimi, Y., Yamaoka, K. (1992) “Swimming-induced head twitching” in rats in the forced swimming test induced by overcrowding stress: A new marker in the animal model of depression? The Keio Journal of Medicine, vol. 41, no. 4, pp. 221–224. https://www.doi.org/10.2302/kjm.41.221 (In English)

Ramsden, E. (2009) The urban animal: Population density and social pathology in rodents and humans. Bulletin of the World Health Organization, vol. 87, no. 2, p. 82. https://www.doi.org/10.2471/blt.09.062836 (In English)

Reber, S. O., Birkeneder, L., Veenema, A. H. et al. (2007) Adrenal insufficiency and colonic inflammation after a novel chronic psycho-social stress paradigm in mice: Implications and mechanisms. Endocrinology, vol. 148, no. 2, pp. 670–682. https://www.doi.org/10.1210/en.2006-0983 (In English)

Sadowski, H., Ugarte, B., Kolvin, I. et al. (1999) Early life family disadvantages and major depression in adulthood. The British Journal of Psychiatry, vol. 174, no. 2, pp. 112–120. https://www.doi.org/10.1192/bjp.174.2.112 (In English)

Sethi, G. R. (1992) Environment and acute respiratory infections. ICCW News Bulletin, vol. 40, no. 3–4, pp. 27–29. PMID: 12318354. (In English)

Sprivulis, P. C., Da Silva, J.-A., Jacobs, I. G. et al. (2006) The association between hospital overcrowding and mortality among patients admitted via Western Australian emergency departments. The Medical Journal of Australia, vol. 184, no. 12, pp. 208–212. https://www.doi.org/10.5694/j.1326-5377.2006.tb00416.x (In English)

Uarquin, D. G., Meyer, J. S., Cardenas, F. P., Rojas, M. J. (2016) Effect of overcrowding on hair corticosterone concentrations in juvenile male Wistar rats. Journal of the American Association for Laboratory Animal Science, vol. 55, no. 6, pp. 749–755. PMID: 27931312. (In English)

Williams, E. D., Steptoe, A., Chambers, J. C., Kooner, J. S. (2009) Psychosocial risk factors for coronary heart disease in UK South Asian men and women. Journal of Epidemiology and Community Health, vol. 63, no. 12, pp. 986–991. https://www.doi.org/10.1136/jech.2008.084186 (In English)

Загрузки

Опубликован

2021-05-27

Выпуск

Раздел

Обзоры