Участие ванилоидных рецепторов 1 типа в защитных и патологических механизмах в желудке при действии ульцерогенных стимулов
DOI:
https://doi.org/10.33910/2687-1270-2021-2-2-147-156Ключевые слова:
ванилоидные рецепторы 1 типа, капсаицин-чувствительные афферентные нейроны, сенситизация, десенситизация, индометацинАннотация
Ванилоидные рецепторы 1 типа (TRPV1— transient receptor potential vanilloid 1) играют ключевую роль в ноцицепции, а также в воспалении, и являются терапевтической «мишенью» для лечения как хронической боли, так и ряда других патологических состояний, среди которых онкологические и сердечно-сосудистые заболевания, ожирение, диабет, воспаление кишечника. TRPV1-рецепторы, основным агонистом которых является капсаицин, экспрессируются в нервных волокнах капсаицин-чувствительных афферентных нейронов (КЧН). КЧН вовлекаются в поддержание целостности слизистой оболочки желудка при действии ульцерогенных стимулов. КЧН рассматриваются как «система тревоги», обеспечивающая быстрый запуск гастропротективных механизмов. Активация КЧН осуществляется через TRPV1-рецепторы. В настоящем обзоре проанализированы данные о вовлечении КЧН и TRPV1-рецепторов как в защитные, так и в патологические механизмы в желудке в условиях действия ульцерогенных стимулов. Особое внимание уделено сравнению экспериментальных данных, полученных с помощью различных подходов, включающих активацию и выключение из функционирования TRPV1-рецепторов. Обсуждены данные о взаимодействии КЧН и глюкокортикоидных гормонов в поддержании целостности слизистой оболочки желудка. Результаты, полученные авторами, свидетельствуют о вовлечении глюкокортикоидных гормонов в реализацию гастропротективного действия КЧН, а также демонстрируют компенсаторную защитную роль данных гормонов в поддержании целостности слизистой оболочки желудка в условиях выключения из функционирования КЧН.
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