GABAa receptor regulation of extracellular taurine level in the nucleus accumbens

Authors

DOI:

https://doi.org/10.33910/2687-1270-2022-3-4-455-462

Keywords:

taurine release, nucleus accumbens, in vivo microdialysis, GABAa receptors, bicuculline, muscimol

Abstract

Taurine is an endogenous GABAa receptor agonist that enhances GABAergic transmission. The article reports the results of the study that investigated the recurrent GABAergic effects mediated by GABAa receptors on taurine release in the nucleus accumbens. The study is relevant due to the growing evidence indicating the involvement of taurine in the regulation of the nucleus accumbens functions and, at the same time, due to the lack of evidence showing GABAa-dependent mechanisms of taurine release regulation in this brain area. Using in vivo microdialysis and high-performance liquid chromatography combined with electrochemical detection in Sprague-Dawley rats, we have shown that administration of the GABAa receptor agonist muscimol (10 μM, 50 μM) into the nucleus accumbens dose-dependently reduces the concentration of extracellular taurine in this brain area. Intra-accumbal administration of the GABAa receptor antagonist bicuculline (20 μM, 60 μM), on the contrary, increased the concentration of extracellular taurine, also in a dose-dependent manner. The obtained data indicate that taurine release in the nucleus accumbens is under tonic inhibitory GABAa-dependent control. This feedback mechanism operating via taurine release may be responsible for the homeostatic regulation of GABAergic activity in the nucleus accumbens.

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Published

2022-12-30

Issue

Vol. 3 No. 4 (2022)

Section

Experimental articles

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