Effect of stress preconditioning and postconditioning on the development and healing of indomethacin-induced gastric erosion
DOI:
https://doi.org/10.33910/2687-1270-2022-3-4-490-499Keywords:
indomethacin, gastric mucosa, erosion, healing, gastroprotection, stress preconditioning, stress postconditioning, glucocorticoidsAbstract
Nonsteroidal anti-inflammatory drugs (NSAIDs), including indomethacin, are commonly used, their use, however, is associated with risks, including injuries of gastric mucosa and the development of gastric erosion. One of the non-drug approaches is stress preconditioning with moderate exposures to protect the gastric mucosa against injury caused by severe exposures. The aim of this work was to study the effects of stress pre- and post-conditioning on the development and healing, respectively, of gastric erosions induced by indomethacin (35 mg/kg). As stress pre- and post-conditioning, the study involved 30-min immobilization of rats in plastic cages at a temperature of 6 °C followed by 1-h immobilization at room temperature (20–22 °C). In experiments with preconditioning, rats were decapitated 4 hours after indomethacin injection to assess the effect on the development of gastric erosion. In experiments with postconditioning, rats were decapitated 24 hours after the development of gastric erosion to assess the healing of erosions. During decapitation, blood samples were collected to estimate the blood glucocorticoids levels. According to the obtained results, stress preconditioning had no significant effect on the development of gastric hemorrhagic erosions induced by indomethacin. At the same time, stress post-conditioning accelerated the healing of indomethacin-induced gastric erosions. Thus, the same stressor may either affect or fail to affect the gastric mucosa, depending on its application as pre- or post-conditioning.
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