Regeneration of first auditory neuron action potential by a weak magnetic field in patients with hearing loss
DOI:
https://doi.org/10.33910/2687-1270-2024-5-4-357-364Keywords:
sensorineural hearing loss, voltage-gated ion channels, membrane depolarization, first auditory neuron, action potential, weak alternating magnetic fieldAbstract
Sensorineural hearing loss can result not only from damage to the auditory apparatus or central auditory pathways but also from cellular dysfunction at the neuronal level, particularly in the first auditory neuron. A key issue may involve the absence or inadequate generation of the action potential (AP) in this neuron. To address this, we have developed a device for the non-invasive application of a weak (less than 300 μT) alternating magnetic field, designed to activate voltage-gated Na+, K+, and Ca2+ ion channels in the first auditory neuron. The sequential opening of these channels induces membrane depolarization, generating an AP and restoring neuronal conductivity. Improvement in hearing was observed in patients with neural hearing loss (degree III and IV) who use hearing aids. The exposure time to the alternating magnetic field varied depending on the diagnosis and the patient’s age. This article reports a hearing improvement of approximately 10 dB in an adult patient following a single 20-minute session and a 20–40 dB improvement in children after a 10-minute session. However, the new sensitivity threshold achieved through electromagnetic stimulation remains unstable and requires further treatment sessions along with appropriate acoustic support.
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