Stimulus-specific adaptation in neuronal responses in the primary auditory cortex of awake mice: A model of mouse pups wriggling call sequences
DOI:
https://doi.org/10.33910/2687-1270-2024-5-3-318-324Keywords:
hearing, primary auditory cortex, awake mice, stimulus-specific auditory adaptation, single neuronsAbstract
This study is the first to investigate the neurophysiological effects of stimulus-specific adaptation (SSA) on the activity of single neurons in the primary auditory cortex of awake house mice. While adaptation of neuronal responses to sound sequences consisting of four identical tones, the time intervals between which were selected so as to be similar to the temporal structure of series of mouse pups wriggling call, adult females were stimulated by a fifth tone signal, the frequency of which differed from the frequency of the first four tone pulses in the series. A fifth tone, differing in frequency from the first four, was presented to stimulate adult female mice. Following the presentation of the deviant tone, a recovery in neuronal responses was observed, either complete or partial, indicating a stronger response to the fifth tone compared to the second through fourth tones. The recovery was frequency-dependent, with the most pronounced effects occurring when the fifth tone frequency was 0.4–0.6 octaves lower or 0.2–0.4 octaves higher than the characteristic frequency of the neuron. These findings highlight the crucial role of SSA in shaping neuronal responses to novel stimuli, including the orienting responses to sound.
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