The impact of dipeptide and tripeptide combinations on the development of tissue cultures from different origins
DOI:
https://doi.org/10.33910/2687-1270-2024-5-4-365-374Keywords:
dipeptides, tripeptides, organotypic tissue culture, vessels, lungsAbstract
The development of bioregulatory agents that preserve essential physiological functions in multicellular organisms remains a key priority in modern physiology and medicine. At the Saint-Petersburg Institute of Bioregulation and Gerontology, a novel technology was established for isolating polypeptide complexes from various bovine organs and tissues, which demonstrated significant effects on the organotypic culture of tissues from experimental animals. Chromatographic and mass spectrometry analyses identified the most common amino acid sequences in these polypeptides, leading to the synthesis of dipeptides and tripeptides. Drugs derived from these peptides have been shown to enhance cell proliferation in organ systems composed of tissues from different origins. However, to further optimize the proliferative effects, it is essential to explore the synergistic impacts of peptide combinations. Therefore, the objective of this study was to examine the effects of dipeptide and tripeptide combinations on the development of vascular and pulmonary tissues in sexually mature rats, using organotypic cultures to simulate these tissue environments. This research is particularly relevant in the context of the increasing significance of metabolomic analysis in advancing systems biology and molecular medicine.
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Yamaguchi, Y., Yamamoto, K., Sato, Y. et al. (2016) Combination of aspartic acid and glutamic acid inhibits tumor cell proliferation. Biomedical Research, vol. 37, no. 2, pp. 153–159. https://doi.org/10.2220/biomedres.37.153 (In English)
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