Proliferative effect of peptides on rat immune system organs
DOI:
https://doi.org/10.33910/2687-1270-2025-6-2-181-189Keywords:
cell proliferation, apoptosis, polypeptide complexes, short peptides, organotypic tissue culture, spleen, thyroid glandAbstract
An imbalance between cell proliferation and death in the immune system organs is crucial to the pathogenesis of various human diseases, including cancer and autoimmune disorders. Similar dysregulations also occur in agriculturally significant animals, impacting food security. Identifying biologically active molecules that modulate proliferation and apoptosis is, therefore, a pressing concern in physiology, medicine, and veterinary science. This study aims to identify the effects of polypeptide complexes (PPCs) and short peptides on cell proliferation in organotypic cultures of rat immune tissues — the spleen and thyroid gland. These organs are central to the functioning of the body’s immune system, stimulating immune cells to combat infection. We investigated AUC (thymalin) and the short peptides Lys-Asp-Glu-Gly, Glu-Asp-Pro, Glu-Asp-Arg, and Lys-Glu-Asp impact the immune tissue of rats at effective concentrations. The peptides are found to induce a statistically significant stimulation of cellular proliferation in explants of both the spleen and thyroid gland. These findings provide a foundation for the targeted development of novel therapeutics for immune system pathologies.
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