Stimulatory effect of peptides on the rat respiratory system
DOI:
https://doi.org/10.33910/2687-1270-2025-6-3-329-337Keywords:
cell proliferation, short peptides, organotypic tissue culture, lungs, bronchi, bronchial arteryAbstract
A central objective in modern physiology and medicine is the identification of biologically active substances capable of enhancing cellular proliferation in vertebrate organs, including those of humans. Proliferation is essential for tissue repair and homeostasis — processes critical to the respiratory system. These include the regeneration of the airway epithelium following injury or inflammation and the continual cellular turnover required for normal pulmonary function. Given the respiratory system’s vital role and its susceptibility to damage, developing novel supportive therapies is of significant importance. Peptide-based therapy represents a promising approach for restoring respiratory function at the cellular level. This study aimed to characterize the effects of short peptides on cell proliferation within organotypic cultures of the rat respiratory system, specifically lung, bronchial artery, and bronchial tissues. The tetrapeptide Ala-Asp- Glu-Arg and the tripeptide Lys-Glu-Asp were found to stimulate cellular proliferation in all the examined tissues. The tripeptide Ala-Glu-Asp increased the proliferative area index in bronchial and lung tissue cultures, whereas Glu-Asp-Gly exerted this effect only in lung tissue culture. These findings provide a foundation for the targeted development of novel therapeutics aimed at restoring respiratory system function.
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