Physiology of mechano- and electroreceptors: From receptor structures to receptor proteins
DOI:
https://doi.org/10.33910/2687-1270-2025-6-4-445-455Keywords:
sensory systems, physiological receptor structures, mechanoreceptors, electroreceptors, receptor proteinsAbstract
This article presents a brief overview of research findings in the field of mechanoreceptor and electroreceptor sensory systems, based on the outstanding contributions by Oleg B. Ilyinsky and his colleagues, — work that remains relevant to this day. As early as 1965, Ilyinsky published an article in Nature demonstrating directional sensitivity of a receptor structure (the Pacinian corpuscle), thereby directly predicting the existence of protein molecular structures — mechanosensitive ion channels — in the nerve terminal of this physiological receptor. Fundamental research into the mechanoreceptor system brought Oleg Ilyinsky and his school worldwide renown in the last century, as confirmed by the international conference he organized in 1974, held at the I. P. Pavlov Institute of Physiology of the USSR Academy of Sciences. Nearly half a century later, the primary amino acid sequences of the receptor proteins — the mechanosensitive Piezo channels were identified, a discovery that led to David Julius and Ardem Patapoutian receiving the Nobel Prize in 2021. The pioneering work of Oleg Ilyinsky and his colleagues made an equally significant contribution to understanding the physiological mechanisms of the electroreceptor system, possessed by some species of fish, amphibians, and mammals. Studies of this sensory organ in fish enabled Oleg Ilyinsky and his team to discover the physiological mechanism by which these animals perceive the Earth’s magnetic field. This review examines the impact of this remarkable scientist’s research findings and conceptual insights on contemporary trends in the development of integrative physiology in the field of sensory systems, using mechano- and electroreception as an example.
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REFERENCES
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