Cognitive impairment in the offspring of male rats exposed to stress in “stress — restress” or “learned helplessness” paradigms: The role of insulin-like growth factor 2
DOI:
https://doi.org/10.33910/2687-1270-2021-2-1-61-70Keywords:
post-traumatic stress disorder, depression, modeling, offspring, memory, insulin-like growth factor 2, receptor of insulin-like growth factor 2, hippocampus, ratAbstract
Psychopathologies such as depression and post-traumatic stress disorder (PTSD), which fathers suffer during reproductive years, can affect the physiological functions of the offspring, including cognitive function and memory. The aim of the study was to compare how the stress in male rats affected the memory of their adult male offspring. The experiment modeled two stress paradigms: PTSD (“stress — restress”) and depression (“learned helplessness”). The methodology included a passive avoidance test and recognition of a new object test. In connection with the involvement of insulin-like growth factor 2 (Igf2) and its receptor type 2 (Igf2r) in memory control, the expression of Igf2 and Igf2r genes in the hippocampus of the offspring was studied by reverse transcription real-time PCR. The study revealed memory impairment in male offspring with a PTSD-like status. It was accompanied by a decrease in the expression of Igf2, but not Igf2r in the hippocampus. The offspring of depressive males did not show impaired memory and gene expression in the hippocampus. We concluded that the influence of the paternal stress on the memory of their offspring may be dependent on the intensity of stress to which the male was exposed. We also concluded that a decrease in Igf2 expression in the hippocampus contributed to impaired memory and the duration of memory retention.
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