Гипоксия и флуоксетин у новорожденных самок крыс повышают производительность пространственной долговременной памяти и реактивность гипоталамо-гипофизарно-адренокортикальной системы во взрослом возрасте

Авторы

DOI:

https://doi.org/10.33910/2687-1270-2023-4-1-79-90

Ключевые слова:

неонатальная гипоксия и флуоксетин, пространственное обучение, память, кортикостерон, взрослая крыса

Аннотация

Исследовано влияние острой нормобарической гипоксии с пониженной концентрацией кислорода во вдыхаемом воздухе и хронического введения селективного ингибитора обратного захвата серотонина флуоксетина у новорожденных самок крысят на способность к пространственному обучению, производительность пространственной кратковременной и долговременной памяти и на реактивность гипоталамо-гипофизарно-адренокортикальной системы (ГГАКС) во взрослом возрасте. Обнаруженные новые данные свидетельствуют об ухудшении способности к пространственному обучению только в первый из пяти тренировочных дней. Гипоксия не изменила производительность памяти в тесте «распознавание нового объекта» и вызвала улучшение долговременной памяти в водном лабиринте Морриса, что сочеталось с более высоким содержанием кортикостерона в плазме крови после тестирования долговременной памяти. Флуоксетин не изменил показатели производительности памяти и гормонального показателя как у контрольных, так и гипоксических взрослых крыс. Флуоксетин нормализовал латентный период достижения платформы у гипоксических крыс при тестировании обучения и не снизил показатель долговременной памяти, улучшенный гипоксией. Полученные результаты позволяют предполагать, что неонатальная нормобарическая гипоксия при определенных условиях помогает улучшить память, флуоксетин оказывает протективное влияние на когнитивные способности и ГГАКС у взрослых самок крыс.

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Опубликован

06.04.2023

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