Влияние нарушения синтеза кинуренинов на память у дрозофилы
DOI:
https://doi.org/10.33910/2687-1270-2021-2-1-49-60Ключевые слова:
дрозофила, обучение, память, кинурениновый путь обмена триптофана, нейрокинурениныАннотация
Проблема продолжительности жизни, особенностей медицинской помощи населению пожилого и старческого возраста становится все актуальнее в большинстве стран мира, в том числе и в России. С увеличением продолжительности жизни нейродегенеративные заболевания (НДЗ) выходят в развитых странах на ведущее место. Одна из причин возникновения нейродегенеративных изменений в мозге — нарушение кинуренинового пути обмена триптофана (КПОТ). Мутанты КПОТ дрозофилы представляют собой адекватные модели для экспериментального изучения роли нейрокинуренинов в изменениях мозговых функций, которые приводят к нарушениям обучения и памяти. Известно несколько мутантных линий D. melanogaster, характеризующихся дефектами кинуренинового пути метаболизма триптофана, в том числе vermilion (v1, блок на уровне фермента триптофаноксигеназы, приводящий к отсутствию кинуренинов и накоплению триптофана). Показано, что мутант v1 сохраняет нормальную способность к обучению при формировании как среднесрочной, так и долгосрочной памяти. Дефектов формирования среднесрочной памяти не обнаружено. Напротив, выявлены нарушения сохранения долгосрочной памяти у данного мутанта. Отсутствие 8-суточной долгосрочной памяти у мутанта v1 с подавлением КПОТ может быть следствием дисбаланса кинуренинов.
Библиографические ссылки
ЛИТЕРАТУРА
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Zawistowski, S. (1988) A replication demonstrating reduced courtship of Drosophila melanogaster by associative learning. Journal of Comparative Psychology, vol. 102, no. 2, pp. 174–176. https://www.doi.org/10.1037/0735-7036.102.2.174 (In English)
Zhao, X., Lenek, D., Dag, U. et al. (2018) Persistent activity in a recurrent circuit underlies courtship memory in Drosophila. eLife, vol. 7, article e31425. https://www.doi.org/10.7554/eLife.31425 (In English)
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Copyright (c) 2021 Екатерина Александровна Никитина, Александр Владимирович Журавлев, Елена Владимировна Савватеева-Попова
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