Стресс-вызванная анальгезия: роль гормонов гипоталамо-гипофизарно-адренокортикальной системы
DOI:
https://doi.org/10.33910/2687-1270-2020-1-1-23-31Ключевые слова:
стресс-вызванная анальгезия, гипоталамо-гипофизарно-адренокортикальная система, глюкокортикоидные рецепторы, рецепторы кортикотропин-рилизинг фактора 1 и 2 типа, опиоидные рецепторыАннотация
Одним из адаптивных проявлений стрессорной реакции является кратковременное уменьшение болевой чувствительности у человека и животных, получившее название «стресс-вызванной анальгезии» (СВА). Ключевой системой, активирующейся при стрессе и обеспечивающей адаптацию организма, является гипоталамо-гипофизарно-адренокортикальная система (ГГАКС). Один из механизмов СВА может быть связан с гормонами данной системы, при этом особая роль в регуляции болевой чувствительности принадлежит гормону центрального звена ГГАКС кортикотропин-рилизинг фактору (КРФ) и глюкокортикоидным гормонам, анальгетические свойства которых хорошо известны и используются в клинике. Цель настоящего обзора — на основании результатов собственных исследований и данных литературы проанализировать вклад в развитие СВА механизмов, связанных с КРФ и глюкокортикоидными гормонами, действие которых опосредуется КРФ рецепторами 1 и 2 типа, глюкокортикоидными рецепторами и опиоидными рецепторами.
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